Projects - United States

Project Name:  Heart Inflammation and Mental Stress Study (HIMS)
Institution:  University of Miami
Mentor:  Roger Mcintosh

This study proposes the use of functional neuroimaging to determine whether HIV and/or pre-hypertension (pre-HTN) has an additive or interactive effect on cardiovascular (CV) reactivity via alteredbrain activity and connectivity within structures that control heart rate and blood pressure. The study aims to examine these mechanisms at rest, during mental stress, and following social ostracism, i.e., discrimination. Data will be collected from a total of 72 men and 72 women, aged from 35 to 65 years. The total sample of 144 adults will be divided equally into 4 groups (36 HIV+ pre-HTN, 36 HIV+ NTN, 36 HIV-pre-HTN, and 36 HIV-NTN.

 

Project Name:  The Effects of Cannabinoids and Route of Cannabis Administration on Subclinical Cardiovascular Disease Risk (The Herbal Heart Study)
Institution:  University of Miami
Mentor:  Denise Christina Vidot

The objective of this study is to examine the impact of THC/CBD levels by route of cannabis administration among cannabis users and nonusers (N=400) aged 18-35 years on objective measures of subclinical CVD risk. Urine and blood samples will quantify levels of THC/CBD among cannabis users. We will examine the impact of THC/CBD on subclinical CVD risk via: 1) traditional CVD risk factors [i.e., central adiposity indexed by waist circumference, blood pressure, (BP) and fasting lipid profile, glucose, insulin, and CRP]; 2) measures of vascular function (i.e., brachial artery reactive hyperemia testing to evaluate vascular endothelial function, and measurements of arterial stiffness). Measurement will occur at baseline and 12-month follow-up via two phases. Phase I will address differences between the groups across subclinical CVD risk. Phase II will examine how THC/CBD levels impact the measured variables within the cannabis user groups. 

 

Project Name:  The International COVID-19 Cannabis Health Study 
Institution:  University of Miami
Mentor:  Denise Christina Vidot

Clinical indications for medicinal cannabis include chronic conditions; thus users are at an increased risk of morbidity and mortality resulting from SARS-CoV-2 infection (COVID-19). The International COVID-19 Cannabis Health Study aims to provide data on cannabis use and self-reported behavioral changes among cannabis consumers in response to the pandemic. The study obtains epidemiologic data on the impact of a rapidly evolving pandemic (COVID-19) on mental and physical health among adults via electronic survey. The secondary aim is to examine potential changes in frequency, dose, and route of cannabis use patterns based on COVID-19 related closures and updates among individuals who endorse cannabis use. An exploratory aim is to examine the sharing of inhaled cannabis products among users as a contributing factor to the spread of the novel coronavirus.